The Lafayette men fell to 0-4 in the Patriot League with an 89-78 loss to Boston U. on Saturday.
The loss was the sixth in a row overall for the Leopards.
Dan Trist had a game-high 19 points in a losing effort for Lafayette.
The Lafayette women picked up their first Patriot League win of the season, winning 68-63 on the road at Boston.
The Leopards are now 1-3 in conference play.