Dieruff's Chris Marks hit Tyshyn Harmon for a 52-yard touchdown with just 2:30 to play to earn a 20-14 win at Pius X on Saturday.
That score broke up a 14-14 tie and gave the Huskies their second consecutive win.
Dieruff is now 2-2 on the season, while Pius X drops to 1-3.
In the Colonial League, Pen Argyl picked up a 21-3 win over Wilson at Smith Field.
The Green Knights improve to 3-1, while Wilson falls to 0-4.