A box trailer turned onto its side on Route 422 East at the Route 222 ramp. Police said it's the ramp that goes from the Warren Street Bypass Eastbound to 222 North, near the Inn at Reading.
The crash happened after 9 a.m.
Police said an accident reconstruction team was at the site investigating how the crash happened, but it's possible speed was a factor.
The ramp was closed for several hours, but reopened Saturday afternoon, officials said.
Authorities said the truck driver went to the hospital for an observation but was released.