Close to 40 million cars are expected to be on the road this Thanksgiving weekend, heading to see family all across the country.
Police are on the lookout for anyone who may be drinking and driving with additional DUI checkpoints over the next several days.
Allentown police said they've actively stepped up enforcement, with roving patrols and more officers on the street.
The Pennsylvania State Police reported 64 traffic crashes throughout Bucks, Lehigh and Northampton counties over the Thanksgiving weekend in 2011. One person died and 14 were injured. Thirteen of the accidents were alcohol-related, officials said.
Police said Thanksgiving Eve is the biggest drinking night of the year and leads to an increase in arrests as college students return home, many for the first time since the summer.
Police said they will be out during all hours of the day and night, enforcing the speed limit and watching for drunk drivers.